Hit the lenti characterization jackpot with RNA detection on Leprechaun
The Problem
Getting an early read on the titer of intact, RNA-containing lentivirus in a batch is vital for optimizing cell therapy manufacture. Too bad most current methods only work with the purest samples and can’t check how many viral particles contain both capsid and RNA. This makes it impossible to get an accurate lentivirus titer immune to fragmented or damaged viral particles and contaminants.
The Solution
Leprechaun is the only tool that provides complete biophysical characterization of individual lentivirus particles from crude harvest to final product. Using <25 µL sample Leprechaun pairs up single particle sizing with fluorescence microscopy to directly check how many viral particles are the right size, have the correct envelope protein, and contain both capsid and RNA. For the first time ever, you can get an accurate titer of structurally complete, RNA-containing lentivirus at every step of your process.
The Proof
In this webinar you’ll learn how Leprechaun isolates lentivirus from even the crudest samples, checks each virus for capsid and RNA, and sizes everything up to separate aggregates from single viruses. We’ll look at multiple lentivirus batches to show how Leprechaun can help ID the highest quality samples early on, and compare samples from different purification stages to shed light on what’s really going on during your purification process. Revolutionize your lentiviral analytics with Leprechaun and ensure your preps always meet the highest standard.
